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Anti Aging Benefits of NR and NMN Supplements

Last updated: April-27,2022

Anti-Aging Benefits of NR and NMN Supplements

The dietary supplement industry is seeing an increase in demand for NMN (Nicotinamide mononucleotide) and NR (Nicotinamide riboside) supplements.

What drives the rising interest in these products, and why do supplement brand owners need to consider adding them to their portfolio sooner rather than later?

The short answer is - Anti-aging. But, to help brand owners understand the basis of this supplement market opportunity and to be able to leverage it effectively, we’ve laid out detailed answers to common questions about NR and NMN supplements.

To know the anti-aging benefits of NMN supplements, let’s first understand aging and its connection with NMN and NR.

What is Aging?

Aging is often defined as the continuous complex multi-factorial process that leads to the decline of bodily functions with time progression.

As we age, the mitochondria, better known as the powerhouse of the cells, lose their natural ability to produce NAD (nicotinamide adenine dinucleotide) effectively. NAD, in turn, is a crucial co-factor for the mitochondrial metabolic activity that produces energy for the body. A reduction in NAD production naturally leads to an age-related decline in the body. Up to 50% of the cells’ ability to produce NAD is lost between the ages of 40 and 60. [i][ii]

This is where NR and NMN supplements can help due to NMN’s crucial role in NAD production.

What is the Role of NR and NMN Supplements in Anti-aging?

Let’s start with looking at the connection between NR, NMN and NAD+ production to understand this better.

Nicotinamide mononucleotide (NMN) is a precursor of NAD+, an essential molecule that plays a crucial role in over 400 metabolic reactions. NMN is a naturally occurring molecule that plays a vital role in the production of NAD+ in the body. [iii]Nicotinamide riboside (NR) and NMN work together perfectly. NMN is converted to NR through extracellular dephosphorylation, in simple terms - removing the extra phosphate from NMN to make it small enough to be transported through the cell wall. This NR enters the cell and is converted back into NMN by the enzyme nicotinamide riboside kinase (NRK). NMN is then transported to the cytoplasm of cells across the cell membranes with the help of another enzyme called Slc12a8 to help promote the production of NAD+.[iv]

Reduced levels of NAD+ directly link to the increase of age-related aging in humans; it has also been noted that an increase in the levels of the molecule could have beneficial effects on age-related issues.[v] This has led to the growing interest in NMN as a dietary supplement and its promising role in delaying the effects of aging.

What are the Important NR and NMN Supplement Benefits?

With the help of science, the average life expectancy of humans has gradually increased over time. The number of individuals over the age of 80 is projected to triple in 30 years. Since a longer life span isn’t a guarantee of a healthy life, solutions to help with age-related problems are an immediate need. [vi]This is where NMN supplements can help. There are several potential health benefits associated with these supplements, making them a welcome addition to any dietary brand owner’s product roster. 

NR and NMN Supplements:

Benefits of NR and NMN Supplements Infographic

Promote Vascular Health and Blood Flow

Studies on NMN and NR supplements have shown their role in helping bring about a significant decline in age-related issues with vascular health and normal blood flow - regularization of oxidative stress and blood vessel flexibility. These studies have also recorded how NR and NMN support changes in gene expression and enhance the ability of cells to keep dividing (keeping cells healthy for longer). [vii]

Improve Strength and Muscle Endurance

Our skeletal muscles are responsible for strength, mobility, and stability. These muscles need many key energy molecules to remain strong, including glucose and fatty acids. These energy molecules are metabolized with the help of NAD+. Since NMN is a precursor of this crucial molecule, having a steady supply of NMN helps in constant energy production, which results in better muscle endurance and overall strength.

Help Maintain Cardiac Function

The heart needs a constant supply of energy to keep functioning. Supplementing with NMN has been shown to increase the production of NAD+ which can play a role in helping to maintain healthy cardiovascular energy levels.

Aid in DNA Repair

NAD+ helps activate several proteins collectively known as sirtuins. These proteins are responsible for maintaining the integrity of our DNA and protecting it from DNA-altering substances, also known as mutagens. Damage to an individual’s DNA can impair cell functioning and cause cell loss. Since sirtuins rely on NAD+ for their proper functioning, NMN supplements can also help preserve and maintain our DNA’s integrity.

Increase Mitochondrial Function

Mitochondria are the cell’s powerhouse, and without these, the human body would not exist. NAD+ helps mitochondria metabolize energy for the cells, allowing them to function correctly. Since NMN is a crucial part of NAD+ production, maintaining its levels is critical for healthy mitochondrial functioning. [viii]

The NR and NMN Supplements – Anti-aging Market Opportunity

The size of the global anti-aging market in 2020 was a whopping $58.5 billion. Projections show that the US anti-aging market alone is expected to grow to $88.30 billion by 2026 (CAGR 7.10% between 2021-2026). [ix]

Anti Aging Supplements Market Size

This being said, the global market for NMN supplements alone was estimated at $253 million in 2020. Further projections show that by the end of 2027, this number is likely to reach $386 million. This has led to an increase in research to find more associated or direct benefits of NMN supplements. To keep up with this demand, a growing number of dietary supplement brands are actively working towards creating their own NR and NMN supplement products. [x]

How Can NutraScience Labs Help?

If you’re thinking about creating customized NR and NMN supplements, look no further than NutraScience Labs. Our team possesses over 120 years of supplement manufacturing experience and has helped more than 2,300 dietary supplements brands create and bring high-quality products to the market.

We specialize in providing brands with-

  • Best-in-class supplement manufacturing services
  • Award-winning packaging and labeling solutions
  • Convenient order fulfillment services
  • Comprehensive customer care – from initial contact to finished product & beyond

To start the process of manufacturing NR and NMN supplements, call 855-492-7388 to speak with one of our knowledgeable production specialists or request your free price quote.


[i] https://healthfullyeverafter.co/food-nutrition-recipe-blog/2019/10/17/aging-and-energy-improvement-should-i-take-nr-and-nmn-supplements-as-nad-boosters

[ii] https://www.pensummed.pro/blogs/nad-the-secret-of-life-and-anti-aging

[iii] https://www.nmn.com/what-is-nmn

[iv] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/

[v] https://www.nmn.com/what-does-nmn-do

[vi] https://www.nmn.com/nmn-benefits-side-effects-dosage

[vii] https://pubmed.ncbi.nlm.nih.gov/31463647/

[viii] https://www.nmn.com/nmn-benefits-side-effects-dosage

[ix] https://www.imarcgroup.com/anti-aging-market

        [x] https://www.nature.com/articles/d42473-022-00002-7



April 27th, 2022

About the Author:

Gene Bruno

Gene Bruno, MS, MHS, RH(AHG) - Mr. Bruno possesses over 42 years of dietary supplement industry experience. With a Master's degree in nutrition and a second Master's degree in herbal medicine, he has a proven track record of formulating innovative, evidence-based dietary supplements. Mr. Bruno currently serves as both the Senior Director of Product Innovation at Twinlab Corporation and Professor of Nutraceutical Science at Huntington University of Health Sciences.